A 46 year old woman was diagnosed with ductal carcinoma in situ on a core biopsy specimen; the case presented is from the excisional biopsy specimen.
Diagnosis and discussion:
Low grade ductal carcinoma in situ, involving an intraductal papilloma, with biopsy site changes.
Papillary lesions are frequently friable, and easily disrupted by biopsy procedures. This small group of glands (image 3) is arranged in a linear fashion, and entrapped within granulation tissue, characteristic of epithelial displacement from the previous biopsy procedure. The cribriform architecture is identical to that of the DCIS; often degenerating fibrovascular cores may be seen associated with entrapped epithelium. Myoepithelial cells are often disrupted as well, with little or no p63 expression.